Publications by authors named "F Louis"
Benralizumab is a monoclonal antibody directed toward the α subunit of the interleukin-5 receptor. This drug has been established as a key treatment for severe hypereosinophilic asthma. Here we report results of the PROMISE study, an observational study conducted in 73 severe asthmatic patients treated at the asthma clinic of CHU Liège and whose blood eosinophil count was > 300/µl.
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- - This study explores how pentachlorophenol (PCP) reacts with hydroxyl (OH) radicals in the gas phase, using advanced computational methods like DFT and coupled cluster theory to analyze the degradation processes and identify byproducts.
- - The research finds that reactions involving chlorine and OH abstractions are not favorable, while hydrogen abstraction and OH addition are more energetically viable and release energy.
- - Rate constants for these reactions were calculated across a range of temperatures, with an estimated atmospheric lifetime for PCP of 1 to 12-16 years at 298 K, depending on OH concentrations.
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- Multiple sclerosis (MS) is difficult to diagnose and manage, often leading to late treatment; however, artificial intelligence (AI) shows promise in analyzing patient data to improve diagnosis.* -
- This study employed a machine-learning approach to analyze metabolite profiles in MS patients and healthy controls, uncovering unique biochemical changes linked to disease severity.* -
- A trained AI model achieved high accuracy rates (87% overall, with good sensitivity, specificity, and precision), indicating potential for clinical use, but further validation with larger studies is required.*
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- Skin macrophages are crucial in how the skin reacts to external factors, and human skin equivalents (HSEs) with THP-1 cells help study this interaction.
- Research showed that THP-1 cells in HSEs have changes in gene expression related to extracellular matrix and DNA replication when exposed to UVA light, causing damage like DNA double-strand breaks.
- Applying a protective agent, mycosporine-2-glycine, reduced these DNA damages and inflammation, indicating that HSEs are a valuable tool for studying skin-macrophage responses to various stimuli.
Obesity and its associated comorbidities place a substantial burden on public health. Given the considerable potential of brown adipose tissue in addressing metabolic disorders that contribute to dysregulation of the body's energy balance, this area is an intriguing avenue for research. This study aimed to assess the impact of various polymers, including collagen type I, fibronectin, laminin, gelatin, gellan gum, and poly-l-lysine (PLL), on the brown adipogenic differentiation of dedifferentiated fat cells within a fibrin gel matrix.
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