The influence of intraperitoneal injections of histamine on tumour growth in fibrosarcoma-bearing mice.

Twenty C57BL/6 male and 20 C3H female mice carrying a methyl cholanthrene-induced fibrosarcoma received, daily, intraperitoneal injections of histamine dihydrochloride (1.8 mg or 6 mg histamine base/mouse). In all histamine-treated C57BL/6 mice, tumour growth was significantly slower than in control mice until day 18.

Cyclophosphamide induction of splenic suppressor cells in hamsters.

Injection of hamsters with a single sublethal dose of cyclophosphamide induced splenic atrophy followed by considerable hypertrophy. During the splenomegaly phase, the in vitro reactivity of spleen cells to concanavalin A (ConA) or protein A (ProtA) was decreased. The spleens of 6-8-month old animals contained cells able to suppress the in vitro reactivity of normal lymphocytes to ConA or ProtA.

Antigens of gastric and intestinal mucous cells in human colonic tumours.

Using immunofluorescence methods, 3 antisera respectively stain 3 groups of mucous cells of the human gastrointestinal tract, showing specific antigens for each group of cells. The antigens of the first group, the M1 antigens, were principally associated with columnar cells of the gastric epithelium, the M2 antigens with mucous cells of gastric and Brünner's glands, and the M3 antigen with the goblet cells of the intestinal mucosa. The gastric M antigens normally detectable in stomach and duodenum (but not in colon) were expressed in certain colonic tumours (benign or malignant) and in adjacent mucosa.