Publications by authors named "F Lo Coco"
Article Synopsis
- Acute myeloid leukemia (AML) is a type of blood cancer with unclear genetic risk factors, and this study explores its hereditary aspects through a meta-analysis.
- Researchers analyzed data from four studies involving 4,018 AML patients and 10,488 controls, finding significant genetic risk loci at two locations: 11q13.2 related to KMT5B and 6p21.32 related to HLA.
- The study enhances understanding of AML development and highlights the roles of genes linked to histone methylation and immune response.
Background: The ZBTB16-RARA fusion gene, resulting from the reciprocal translocation between ZBTB16 on chromosome 11 and RARA genes on chromosome 17 [t(11;17)(q23;q21)], is rarely observed in acute myeloid leukemia (AML), and accounts for about 1% of retinoic acid receptor-α (RARA) rearrangements. AML with this rare translocation shows unusual bone marrow (BM) morphology, with intermediate aspects between acute promyelocytic leukemia (APL) and AML with maturation. Patients may have a high incidence of disseminated intravascular coagulation at diagnosis, are poorly responsive to all-trans retinoic acid (ATRA) and arsenic tryoxyde, and are reported to have an overall poor prognosis.
View Article and Find Full Text PDFThe SLIT-ROBO axis plays an important role in normal stem-cell biology, with possible repercussions on cancer stem cell emergence. Although the Promyelocytic Leukemia (PML) protein can regulate expression in the central nervous system, little is known about SLIT2 in acute promyelocytic leukemia. Hence, we aimed to investigate the levels of SLIT2 in acute promyelocytic leukemia (APL) and assess its biological activity in vitro and in vivo.
View Article and Find Full Text PDF