Publications by authors named "F Lienard"
Article Synopsis
- The study aimed to investigate how people with obesity (OB) process taste information compared to normal-weight individuals (NW) by examining gustatory evoked potentials (GEP) in response to a sucrose solution before and after eating a standard lunch.
- Participants included 28 individuals with obesity and 22 normal-weight individuals, who underwent tests in two sessions: one after fasting and one after consuming a low-sugar lunch.
- Results showed that OB subjects had longer GEP latencies, indicating slower activation of the taste cortex, and their GEP responses did not change after eating, unlike NW participants, with correlations found between GEP latencies and certain hormone levels.
Background: The need for early diagnosis biomarkers in Alzheimer's disease (AD) is growing. Only few studies have reported gustatory dysfunctions in AD using subjective taste tests.
Objective: The main purpose of the study was to explore gustatory functions using subjective taste tests and recordings of gustatory evoked potentials (GEPs) for sucrose solution in patients with minor or major cognitive impairment (CI) linked to AD, and to compare them with healthy controls.
Part of hypothalamic (mediobasal hypothalamus [MBH]) neurons detect changes in blood glucose levels that in turn coordinate the vagal control of insulin secretion. This control cascade requires the production of mitochondrial reactive oxygen species (mROS), which is altered in models of obesity and insulin resistance. Obese, insulin-resistant Zücker rats are characterized by hypothalamic hypersensitivity to glucose.
View Article and Find Full Text PDFMaintaining energy balance is essential for survival and health. This physiological function is controlled by the brain, which adapts food intake to energy needs. Indeed, the brain constantly receives a multitude of biological signals that are derived from digested foods or that originate from the gastrointestinal tract, energy stores (liver and adipose tissues) and other metabolically active organs (muscles).
View Article and Find Full Text PDFDespite an extensive theoretical and numerical background, the translocation ratchet mechanism, which is fundamental for the transmembrane transport of biomolecules, has never been experimentally reproduced at the nanoscale. Only the Sec61 and bacterial type IV pilus pores were experimentally shown to exhibit a translocation ratchet mechanism. Here we designed a synthetic translocation ratchet and quantified its efficiency as a nanopump.
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