Publications by authors named "F Lieh Mak"
The optimization of hit compounds into drug candidates is a pivotal phase in drug discovery but often hampered by cumbersome manual synthesis of derivatives. While automated organic molecule synthesis has enhanced efficiency, safety, and cost-effectiveness, achieving fully automated multistep synthesis remains a formidable challenge due to issues such as solvent and reagent incompatibilities and the accumulation of side-products. We herein demonstrate an automated solid-phase flow platform for synthesizing α-keto-amides and nitrile peptidomimetics, guided by docking simulations, to identify potent broad-spectrum antiviral leads.
View Article and Find Full Text PDFObjective: This study aimed to investigate the incidence, risk factors and trends for vaginal cancer.
Design: Retrospective observational design.
Setting: Data were collected from multiple sources, including the Global Cancer Observatory, Cancer Incidence in Five Continents Plus, Global Burden of Disease, World Bank and the United Nations.
Background: Ureteral cancer is a rare cancer. This study aimed to provide an up-to-date and comprehensive analysis on the global trends of ureteral cancer incidence and its association with lifestyle and metabolic risk factors.
Methods: The incidence of ureteral cancer was estimated from the Cancer Incidence in Five Continents Plus and Global Cancer Observatory databases.
Deficits in the ability to read the emotions of others have been demonstrated in mental disorders, such as dissociation and schizophrenia, which involve a distorted sense of self. This study examined whether weakened self-referential source memory, being unable to remember whether a piece of information has been processed with reference to oneself, is linked to ineffective emotion recognition. In two samples from a college and community, we quantified the participants' ability to remember the self-generated versus non-self-generated origins of sentences they had previously read or partially generated.
View Article and Find Full Text PDFArticle Synopsis
- Vulvar cancer is a rare but significant health issue due to its diagnostic and treatment costs, as well as its impact on women's mental health.
- The study analyzes global vulvar cancer incidence trends and risk factors, revealing higher rates in regions like Western Europe and Northern America, with socioeconomic factors contributing to increased cases.
- The incidence is rising overall, particularly among older women, with suggestions for prevention strategies like smoking cessation and HPV vaccination to mitigate future risks.