Publications by authors named "F Levenez"
Background: Antibiotics notoriously perturb the gut microbiota. We treated healthy volunteers either with cefotaxime or ceftriaxone for 3 days, and collected in each subject 12 faecal samples up to day 90. Using untargeted and targeted phenotypic and genotypic approaches, we studied the changes in the bacterial, phage and fungal components of the microbiota as well as the metabolome and the β-lactamase activity of the stools.
View Article and Find Full Text PDFArticle Synopsis
- Anorexia nervosa (AN) is a serious eating disorder mostly affecting women, with about 1% of the population having it, but effective treatments aren't widely available.
- Researchers studied the gut microbiota (the tiny bacteria in our stomachs) of 77 women with AN and 70 healthy women, finding that those with AN had changes in their bacteria and viruses that might affect their eating habits and mental health.
- They also discovered that these changes in gut bacteria could lead to less food intake and affect how the body uses energy, suggesting that the microbiome plays a role in causing AN.
Background: Multiple sclerosis is a chronic immune-mediated disease of the brain and spinal cord resulting in physical and cognitive impairment in young adults. It is hypothesized that a disrupted bacterial and viral gut microbiota is a part of the pathogenesis mediating disease impact through an altered gut microbiota-brain axis. The aim of this study is to explore the characteristics of gut microbiota in multiple sclerosis and to associate it with disease variables, as the etiology of the disease remains only partially known.
View Article and Find Full Text PDFObjective: Gut microbiome dysbiosis has previously been reported in spondyloarthritis (SpA) patients and could be critically involved in the pathogenesis of this disorder. The objectives of this study were to further characterize the microbiota structure in SpA patients and to investigate the relationship between dysbiosis and disease activity in light of the putative influence of the genetic background.
Methods: Shotgun sequencing was performed on fecal DNA isolated from stool samples from 2 groups of adult volunteers: SpA patients (n = 102) and healthy controls (n = 63).
Article Synopsis
- An imbalance in gut bacteria (dysbiosis) is linked to chronic diseases, and dietary soluble fiber, particularly resistant dextrin (RD), may help restore balance.
- A study with 50 healthy women showed that RD supplementation for 6 weeks significantly increased the beneficial bacterium Parabacteroides distasonis in their gut microbiota.
- The effect of RD appears to depend on individual responses related to specific strains of bacteria, and further research is needed to explore how P. distasonis might contribute to health benefits.