Publications by authors named "F Leuthard"

Research on naturally occurring hypothyroidism in adult cats is limited to 16 reported cases in the last three decades, highlighting the need for more comprehensive studies. This prospective multicenter study aimed to identify cases of spontaneous primary hypothyroidism (SPH) in adult cats presented over a one-year period . Staff members of two university hospitals and one private referral clinic screened for cats aged older than one year showing clinical signs suggestive of feline hypothyroidism including obstipation, obesity/weight gain, lethargy, goiter size, skin changes or mild azotemia.

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We investigated four cats with similar clinical skin-related signs strongly suggestive of Ehlers-Danlos syndrome (EDS). Cases no. 1 and 4 were unrelated and the remaining two cases, no.

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Two retrogenes ( on chromosome 18 and on chromosome 12) have been identified to cause dwarfism across many dog breeds. Some breeds are nearly homozygous for both retrogenes (e.g.

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Article Synopsis
  • X-linked hypohidrotic ectodermal dysplasia-1 (ECTD1) leads to issues like hair loss (hypotrichosis), missing teeth (anodontia/oligodontia), and dysfunctional skin glands, as seen in a study of five calves.
  • The affected calves exhibited severe hair loss, with some dying from pneumonia shortly after birth; histological examination showed mostly unremarkable small hair follicles and a few larger ones in specific areas like the muzzle and eyelids.
  • Genetic analysis revealed a significant deletion in the gene related to ECTD1, which is thought to cause this inheritable skin disorder observed in affected calves.
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Epidermolysis bullosa simplex (EBS) is a hereditary blistering disease affecting the skin and mucous membranes. It has been reported in humans, cattle, buffaloes and dogs, but so far not in cats. In humans, EBS is most frequently caused by variants in the KRT5 or KRT14 genes.

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