Publications by authors named "F Lesueur"
Article Synopsis
- The study checked how well the BOADICEA model predicts breast cancer risk for people who carry certain gene changes (called pathogenic variants).
- They looked at information from a group of over 1,600 participants and found that the model worked really well, especially when considering family history and other risk factors.
- The results can help doctors and patients make better choices about cancer management, and the model can be accessed for free on the CanRisk website.
The Ataxia-Telangiectasia Mutated gene is implicated in DNA double-strand break repair. Controversies in clinical radiosensitivity remain known for monoallelic carriers of the pathogenic variant (PV). An evaluation of the single-nucleotide polymorphism (SNP) rs1801516 (G-A) showed different results regarding late subcutaneous fibrosis after breast radiation therapy (RT).
View Article and Find Full Text PDFBackground: Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium (OCAC), Consortium of Investigators of Modifiers of (CIMBA), UK Biobank (UKBB), and FinnGen to identify novel HGSOC susceptibility loci and develop polygenic scores (PGS).
Methods: We analyzed >22 million variants for 398,238 women.
Article Synopsis
- - The study investigates the genetic links between breast cancer (BC) and thyroid disorders, revealing a positive correlation between BC risk and thyroxine (FT4) levels, and a negative correlation with thyroid-stimulating hormone (TSH) levels, particularly in estrogen receptor-positive BC.
- - Polygenic risk scores indicate that higher FT4 and hyperthyroidism risks are associated with increased BC risk, while higher TSH risk is linked to decreased BC risk, highlighting the role of genetics in these diseases.
- - The research identifies 49 shared genetic loci connected to both BC and thyroid traits and suggests that certain brain and immune system-related genes play significant roles in the relationship between these conditions.
Article Synopsis
- Epidemiological studies have shown mixed results regarding the link between Parkinson's disease (PD) and various cancers, primarily due to methodological challenges.
- This research aimed to explore the genetic correlation between PD and different cancers using data from large genome-wide association studies (GWASs) involving thousands of participants, particularly those of European ancestry.
- Findings revealed a positive genetic correlation between PD and melanoma as well as prostate cancer, while showing inverse associations between PD and ovarian cancer, indicating complex genetic interactions between these diseases.