Publications by authors named "F Lestrade"

Article Synopsis
  • In a case study of a man with severe oligozoospermia and a misdiagnosed macrozoospermia, no harmful variants were found in the AURKC gene, prompting the use of WES which identified a harmful variant in the ZMYND15 gene.
  • The study confirms that bi-allelic variants in ZMYND15 can cause severe oligozoospermia and may lead to misdiagnosis, emphasizing the importance of using comprehensive genetic testing methods like WES when looking for sperm defect causes.
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Objectives: The undeniable asset of the antagonist protocols in in vitro fertilization is the decrease of the risks of ovarian hyperstimulation syndrome, by the use of a release by GnRH agonist. Nevertheless, questioning persist concerning the rates of clinical pregnancies, the oocyte quantity and the empty follicle syndrome. We thus studied these parameters in our center.

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Article Synopsis
  • The study aimed to discover new mutations in the AURKC gene of patients with macrozoospermia and to explore the relationship between their genetic changes and observed phenotypes.
  • Researchers discovered a new non-sense mutation, p.Y248*, which accounts for 13% of all mutant alleles, but found no phenotype differences compared to the previously known main mutation, c.144delC.
  • The study involved 87 patients with primary infertility from multiple countries, where sperm analysis and extensive molecular testing of the AURKC gene were conducted to assess the mutations and their impacts.
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Objective: Frozen embryos' transfer optimize the pregnancy rates per retrieval. In France, 60% of transfer cycles occur in stimulated cycles. The aim of this study was to evaluate the outcomes of frozen embryo transfers in spontaneous, substituted and stimulated cycle.

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