Publications by authors named "F Lesaffre"
Article Synopsis
- - The study aimed to create a population pharmacokinetic-pharmacodynamic (PK-PD) model to understand how different factors influence the variability of unfractionated heparin (UFH) doses in patients undergoing radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF).
- - Analysis of medical records from 668 patients revealed that pretreatments with anticoagulants like dabigatran, warfarin, or fluindione affected baseline activated clotting time (ACT), and the initial UFH dose and previous anticoagulant were key predictors of ACT 15 minutes after UFH administration.
- - The researchers successfully developed predictive calculators for ACT and UFH doses, promoting tailored anticoagulation
Identification of constitutive law for 3d-printed bioresorbable thermosensitive polymer to design medical devices for soft tissue reconstruction.
Comput Methods Biomech Biomed Engin
November 2024
Breast cancer concerns 1 in 8 women in the world and is followed in 40% of cases by a mastectomy. Only 14% of women receive reconstructive surgery because of unfavorable clinical issues. The need of innovative tissue engineering devices leads Lattice Medical company to bring a new 3D-printed device, allowing the regeneration of soft tissue in order to replace the withdrawn breast.
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- SCN5A gene variants are linked to various cardiac electrical disorders, but they can also result in complex phenotypes like overlap syndromes, which haven't been thoroughly studied.
- The study analyzed DNA from over 13,500 patients with a focus on those carrying pathogenic SCN5A variants, finding that most were tied to well-defined conditions like Brugada syndrome and long QT syndrome.
- About 19% of the variants were associated with complex phenotypes, and only a small number (8 out of 9,960 patients) showed a potential link to dilated cardiomyopathies (DCM), suggesting it's a rare association.
This paper presents a low-cost milling system composed of spindle mountable on a multi tool 3D printer equipped with maxwell kinematic coupling (E3D "ToolChanger" in this article) as well as two open-source software solutions for implementing a hybrid FFF/CNC manufacturing process. The first solution is the use of a traditional CAM software (FreeCad) for machining programming through the development of a dedicated post-processor. The second is an automatic layer-by-layer hybridization enabled by the software "SuperSlicer".
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