Publications by authors named "F Leonard"
The objective of this systematic review and meta-analysis is to assess the carcinogenic effects of extremely low frequency magnetic fields (ELF-MF) by analyzing animal and comet assay studies. We have performed a global meta-analysis on all the animal studies on the relation between ELF-MF and cancer incidence and separate meta-analyses on the incidence of cancer, leukemia, lymphoma, breast cancer, brain cancer and DNA damage assessed with the comet assay. Of the 5145 references identified, 71 studies have been included in our systematic review and 22 studies in our meta-analyses.
View Article and Find Full Text PDFBackground: Oral fluid contains analytes that may be reflective of health and welfare in pig herds. Additionally, oral fluid collection is a more convenient and cost-effective option when compared to blood sampling, increasing the potential of oral fluid as a non-invasive alternative tool. While a growing number of biomarkers can be measured in porcine oral fluid, the use of these analytes to compare commercial herds in veterinary practice is still limited.
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- - This study investigates Mycoplasma bovis (M. bovis) infection in cattle, which can cause various health issues, aiming to analyze the genetic diversity of M. bovis strains from clinical samples in Ireland and Scotland.
- - Researchers sequenced the genomes of 24 M. bovis strains (19 from Ireland and 5 from Scotland) and compared them to 117 existing genetic assemblies to create a phylogenetic tree, identifying Irish strains in two groups and all Scottish strains in one.
- - The findings highlight the similarities between Irish and Scottish M. bovis strains and underscore the importance of biosecurity in cattle management due to the global spread of this infection facilitated by international cattle movement.
Article Synopsis
- Free-space all-optical diffractive neural networks are emerging technologies for recognizing and classifying scenes, and understanding their basic properties is crucial for their performance.
- Researchers investigated how the depth of these systems, achieved by adding more diffractive layers, influences classification accuracy while using a co-design modeling method.
- Although increasing depth improves accuracy while using fewer features compared to a single layer, it can't exceed the performance of an optimized single layer, as limitations arise from the fundamental physics of light, particularly the diminishing electric field strength with distance.
Unlabelled: Persistent DNA double-strand breaks (DSBs) are enigmatically implicated in neurodegenerative diseases including Huntington's disease (HD), the inherited late-onset disorder caused by CAG repeat elongations in Huntingtin (HTT). Here we combine biochemistry, computation and molecular cell biology to unveil a mechanism whereby HTT coordinates a Transcription-Coupled Non-Homologous End-Joining (TC-NHEJ) complex. HTT joins TC-NHEJ proteins PNKP, Ku70/80, and XRCC4 with chromatin remodeler Brahma-related Gene 1 (BRG1) to resolve transcription-associated DSBs in brain.
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