Publications by authors named "F Lennmyr"
Background: Rewarming on cardiopulmonary bypass (CPB) is associated with increased metabolic demands; however, it remains unclear whether cerebral autoregulation is affected during this phase. This RCT aims to describe the effects of 20% supranormal, compared to normal CPB flow, on monitoring signs of inadequate perfusion, oxygenation, and disturbed cerebral autoregulation, during the rewarming phase of CPB.
Method: Thirty two patients scheduled for coronary artery bypass grafting were allocated to a Control group ( = 16) receiving a CPB pump flow corresponding to preoperatively measured cardiac output, and an Intervention group ( = 16) receiving the corresponding CPB pump flow increased by 20% during rewarming.
Article Synopsis
- The study tested a heparin conjugate treatment on pig kidneys to see if it can reduce injury from early ischemia-reperfusion.
- During the experiment, the treated kidneys showed better outcomes, such as lower weight, improved urine production, and less damage compared to untreated controls.
- The findings suggest that this heparin treatment could enhance kidney preservation and function, potentially benefiting organ transplant quality.
Optimal PEEP during one-lung ventilation with capnothorax: An experimental study.
Acta Anaesthesiol Scand
February 2019
Background: One-lung ventilation (OLV) with induced capnothorax carries the risk of severely impaired ventilation and circulation. Optimal PEEP may mitigate the physiological perturbations during these conditions.
Methods: Right-sided OLV with capnothorax (16 cm H O) on the left side was initiated in eight anesthetized, muscle-relaxed piglets.
Background: Survivors of cardiac arrest often experience neurologic deficits. To date, treatment options are limited. Associated hyperglycemia is believed to further worsen the neurologic outcome.
View Article and Find Full Text PDFBackground: Perfusion strategies during aortic surgery usually comprise hypothermic circulatory arrest (HCA), often combined with selective antegrade cerebral perfusion (SACP) or retrograde cerebral perfusion. Cerebral blood flow (CBF) is a fundamental parameter for which the optimal level has not been clearly defined. We sought to determine the CBF at a pump flow level of 6 mL/kg/min, previously shown likely to provide adequate SACP at 20°C in pigs.
View Article and Find Full Text PDF