Publications by authors named "F Lejuste"

Article Synopsis
  • - Autism spectrum disorder (ASD) is marked by challenges in social communication and repetitive behaviors, with maternal immune activation (MIA) during mid-pregnancy identified as a risk factor, affecting about 15% of those with ASD.
  • - This study hypothesized that individuals with ASD who experienced MIA would show greater socio-adaptive impairments compared to those without, analyzing data from 295 mother-child pairs, with findings indicating more severe socialization difficulties in the ASD-MIA group.
  • - Limitations of the study include its retrospective nature and a relatively small sample size, underscoring the need for larger prospective studies to explore the specific biological mechanisms behind the socio-adaptive challenges in ASD-MIA individuals.
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Background: While adult outcome in autism spectrum disorder (ASD) is generally measured using socially valued roles, it could also be understood in terms of aspects related to health status - an approach that could inform on potential gender differences.

Methods: We investigated gender differences in two aspects of outcome related to health-status, i.e.

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Autism spectrum disorder (ASD) represents a set of heterogeneous neurodevelopmental conditions defined by impaired social interactions and repetitive behaviors. The number of reported cases has increased over the past decades, and ASD is now a major public health burden. So far, only treatments to alleviate symptoms are available, with still unmet need for an effective disease treatment to reduce ASD core symptoms.

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Autism spectrum disorder (ASD) is a very heterogeneous disorder. Obsessive compulsive disorder (OCD) comorbidity, frequent in ASD, could be useful to define a specific ASD subtype. Our objective was to explore if adults with ASD and comorbid OCD could present a specific clinical profile of ASD in 89 high functioning-adult ASD patients.

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