Publications by authors named "F Legendre"
Double-blinded, randomized tolerance study of a biologically enhanced Nanogel with endothelin-1 and bradykinin receptor antagonist peptides via intra-articular injection for osteoarthritis treatment in horses.
Antoinette Terlinden Sandrine Jacquet Seng Manivong Aurélie Cullier Frédéric Cassé Florence Legendre
BMC Vet Res
December 2024
Article Synopsis
- Osteoarthritis is a major issue for athletic horses, causing pain and leading to early retirement, with hydro-expansive functionalized nanogels being explored as a potential treatment through a double-blinded randomized tolerance study.
- Eight healthy horses received injections of chitosan and hyaluronic acid nanogels and saline as controls, monitored for clinical signs and synovial fluid changes over three months.
- The study found mild synovitis in the treated group following injections, which resolved quickly, and while inflammation markers showed a temporary rise, there were no long-term adverse effects, indicating the treatment could be safe.
Article Synopsis
- Despite advancements in genomics, assessing uncertainty in phylogenomic studies remains challenging, particularly in the phylogenetics of cockroaches and termites, where inconsistencies persist across different research.
- A new phylogenetic analysis of Blattodea was conducted using three methods, including a novel "tiered phylogenetic inference," which integrates data quality into the analysis to better gauge the reliability of phylogenetic relationships.
- This approach highlighted problematic areas with previously high support but low data quality, leading to clearer resolutions of several phylogenetic uncertainties, particularly regarding the relationships within Blaberidae and other families.
Article Synopsis
- - The classification of termites, particularly the diverse Neoisoptera group, needs significant updates due to many incorrectly grouped taxa; researchers propose a new classification based on genomic analyses.
- - The study identifies seven monophyletic family lineages within Neoisoptera and 18 subfamily lineages in the species-rich Termitidae, including several new subfamilies and the revival of some older ones.
- - The new classification method is built on clear monophyletic lineages, which enhances its stability and adaptability for future studies, allowing it to incorporate yet-to-be-discovered species easily.
The Angiosperm Terrestrial Revolution buffered ants against extinction.
Proc Natl Acad Sci U S A
March 2024
With ~14,000 extant species, ants are ubiquitous and of tremendous ecological importance. They have undergone remarkable diversification throughout their evolutionary history. However, the drivers of their diversity dynamics are not well quantified or understood.
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