Publications by authors named "F Le Bourgeois"

Objective: Timely access to data is needed to improve care for substance-exposed birthing persons and their infants, a significant public health problem in the United States. We examined the current state of birthing person and infant/child (dyad) data-sharing capabilities supported by health information exchange (HIE) standards and HIE network capabilities for data exchange to inform point-of-care needs assessment for the substance-exposed dyad.

Material And Methods: A cross-map analysis was performed using a set of dyadic data elements focused on pediatric development and longitudinal supportive care for substance-exposed dyads (70 birthing person and 110 infant/child elements).

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Background: Patient notes contain substantial information but are difficult for computers to analyse due to their unstructured format. Large-language models (LLMs), such as Generative Pre-trained Transformer 4 (GPT-4), have changed our ability to process text, but we do not know how effectively they handle medical notes. We aimed to assess the ability of GPT-4 to answer predefined questions after reading medical notes in three different languages.

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Article Synopsis
  • Cell and gene therapies (CGTs) have shown potential for treating hard-to-treat conditions, but their development is risky for pharmaceutical companies due to uncertainties in clinical trials and regulatory approval.
  • An analysis of CGT products from 1993 to 2023 found that only 5.3% received regulatory approval, with higher chances for products with orphan designation and lower chances for oncology-related therapies.
  • Both CAR T cell therapies and AAV gene therapies showed a similar approval likelihood of 13.6%, highlighting that approval rates vary by product type and therapeutic indication.
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