Publications by authors named "F Lavatelli"
Article Synopsis
- AA-amyloidosis is a common issue in shelter cats, leading to chronic kidney disease, which is the primary cause of death in these animals.* -
- A study analyzed kidney samples from 9 domestic short-hair cats (median age 8 years) post-mortem, revealing all had elevated serum creatinine, proteinuria, and amyloid deposits in both the cortex and medulla.* -
- The findings indicate systemic AA-amyloidosis is prevalent in shelter cats with chronic kidney disease, suggesting these cats can serve as a natural model for studying this condition.*
AL amyloidosis is a life-threatening disease caused by deposition of immunoglobulin light chains. While the mechanisms underlying light chains amyloidogenesis in vivo remain unclear, several studies have highlighted the role that tissue environment and structural amyloidogenicity of individual light chains have in the disease pathogenesis. AL natural deposits contain both full-length light chains and fragments encompassing the variable domain (V) as well as different length segments of the constant region (C), thus highlighting the relevance that proteolysis may have in the fibrillogenesis pathway.
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- The text discusses the ongoing debate about how native human transthyretin (TTR) converts into amyloid fibrils in the body, emphasizing the differences in research conditions used for studying this process.
- It focuses on two specific TTR variants, S52P and L111M, that cause severe systemic amyloidosis, particularly affecting the heart, and highlights their varying stability and susceptibility to proteolytic cleavage.
- The study shows that while both variants are similar in stability, the L111M variant is more prone to cleavage and faster fibril formation when influenced by factors like heparin and fibrillar seeds, indicating complex mechanisms at play in amyloid formation.
Background: Amyloid A (AA) amyloidosis is a protein misfolding disease arising from serum amyloid A (SAA). Systemic AA amyloidosis recently was shown to have a high prevalence in shelter cats in Italy and was associated with azotemia and proteinuria.
Objectives: Investigate urine protein profiles and diagnostic biomarkers in cats with renal AA amyloidosis.