Publications by authors named "F Lattanzio"
Aging phenotype is characterized by musculoskeletal impairment that leads to diminished mobility and physical function. This study investigated whether circulating miRNAs and metabolic and inflammatory biomarkers may reflect the walking performance of the elderly. Elderly hospitalized for an acute condition and recruited from the ReportAge Biobank were grouped, based on their walking performance, in active subjects (n = 23, age: 83.
View Article and Find Full Text PDFBackground: Plasma osteopontin (pOPN) is a promising aging-related biomarker among individuals with and without kidney disease. The interaction between sex, pOPN levels, and global and cardiorenal outcomes among older individuals was not previously evaluated.
Methods: In this study we investigated the association of pOPN with 24-month global mortality, major cardiovascular events (MACEs), MACEs + cardiovascular (CV) mortality, and renal decline among older individuals; we also evaluated whether sex modified observed associations.
Purpose: In this study, a comprehensive analysis of costs of chronic kidney disease (CKD) was performed, to understand factors associated with the economic burden of the disease in a multicentre international framework.
Methods: The impact on costs of demographics, socio-economics, clinical, and functional variables was tested in 2204 subjects aged 75 years or more attending outpatient clinics in Europe using a multicentre 2-year prospective cohort study. By means of collected resources consumption and unit cost data a comprehensive cost database was built and then investigated using multilevel regression modeling.
Article Synopsis
- The study focused on the relationship between Torquetenovirus (TTV) levels, inflammation markers, and the risk of Ischemic Heart Disease (IHD) in older adults, revealing limited research on this topic.
- Findings from 900 non-IHD participants and 86 IHD individuals indicated that elevated TTV viremia was a significant predictor of IHD risk, particularly in males and in conjunction with other health factors like diabetes and smoking.
- The research suggests that high TTV levels are linked to increased inflammation and may contribute to IHD risk through mechanisms related to aging and immune response deterioration.
Article Synopsis
- The study aimed to investigate the relationship between phase angle (PhA), a marker of hydration and nutritional status, and the development of sarcopenia in older adults.
- It involved 696 participants aged 75 and older, assessing them for sarcopenia and related physical capabilities over 24 months using various tests and methods.
- While lower baseline PhA was observed in those who developed sarcopenia, it was not confirmed as a significant predictor after accounting for other related factors, raising questions about its practical use as an early marker for sarcopenia risk.