Publications by authors named "F Lassalle"
Clonal hematopoiesis of indeterminate potential (CHIP) is considered as being a novel age-related risk factor for cardiovascular diseases. By capture-sequencing of a 67-gene panel, we established a large spectrum of CHIP in 258 patients with aortic valve stenosis undergoing transcatheter aortic valve replacement (TAVR) and assessed their association with long-term survival after TAVR. One or several CHIP variants in 35 genes were identified in 68% of the cohort, and being the 2 most frequently mutated genes.
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- Yemen has been facing the largest cholera outbreak in modern history since 2016, with a significant rise in multidrug-resistant (MDR) cholera strains observed since 2018.
- Analysis of 260 V. cholerae isolates from 2018 to 2019 revealed that a majority (84%) were part of the O1 serogroup and belonged to the seventh pandemic El Tor lineage, while the remaining 16% were non-toxigenic strains from different lineages.
- The emergence of MDR plasmids in cholera strains indicates a potential genetic exchange between epidemic and endemic strains, underscoring the need for ongoing genomic surveillance to manage and control cholera effectively.
Ongoing diarrheal disease surveillance throughout Bangladesh over the last decade has revealed seasonal localised cholera outbreaks in Cox's Bazar, where both Bangladeshi Nationals and Forcibly Displaced Myanmar Nationals (FDMNs) reside in densely populated settlements. FDMNs were recently targeted for the largest cholera vaccination campaign in decades. We aimed to infer the epidemic risk of circulating Vibrio cholerae strains by determining if isolates linked to the ongoing global cholera pandemic ("7PET" lineage) were responsible for outbreaks in Cox's Bazar.
View Article and Find Full Text PDFBaculoviruses are entomopathogens that carry large, double-stranded circular DNA genomes and infect insect larvae of Lepidoptera, Hymenoptera and Diptera, with applications in the biological control of agricultural pests, in the production of recombinant proteins and as viral vectors for various purposes in mammals. These viruses have a variable genetic composition that differs between species, with some sequences shared by all known members, and others that are lineage-specific or unique to isolates. Based on the analysis of nearly 300 sequenced genomes, a thorough bioinformatic investigation was conducted on all the baculoviral protein coding sequences, characterizing their orthology and phylogeny.
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- Agrobacterium used to be thought of mainly as bacteria that harm plants, but now it includes both harmful and harmless types.
- Scientists found two new types of Agrobacterium, LMG 31531 and LMG 31532, from soil and plant roots, which are different from other known types.
- These new strains are named Agrobacterium divergens and have special features that help scientists understand how this group of bacteria evolves.