MCT1-dependent lactate recycling is a metabolic vulnerability in colorectal cancer cells upon acquired resistance to anti-EGFR targeted therapy.

Despite the implementation of personalized medicine, patients with metastatic CRC (mCRC) still have a dismal overall survival due to the frequent occurrence of acquired resistance mechanisms thereby leading to clinical relapse. Understanding molecular mechanisms that support acquired resistance to anti-EGFR targeted therapy in mCRC is therefore clinically relevant and key to improving patient outcomes. Here, we observe distinct metabolic changes between cetuximab-resistant CRC cell populations, with in particular an increased glycolytic activity in KRAS-mutant cetuximab-resistant CRC cells (LIM1215 and OXCO2) but not in KRAS-amplified resistant DiFi cells.

Resistance to Gemcitabine in Pancreatic Cancer Is Connected to Methylglyoxal Stress and Heat Shock Response.

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with poor prognosis. Gemcitabine is the first-line therapy for PDAC, but gemcitabine resistance is a major impediment to achieving satisfactory clinical outcomes. This study investigated whether methylglyoxal (MG), an oncometabolite spontaneously formed as a by-product of glycolysis, notably favors PDAC resistance to gemcitabine.

Gastric Duplication Cyst with Respiratory Epithelium: a Rare Entity.

Gastric duplication cyst is an uncommon entity and management is principally surgical. Diagnosis is often delayed because of the non-specific nature of symptoms. The authors report one case of gastric duplication cyst incidentally diagnosed in a 23-year-old man.

Aneurysm of the splenic artery which arises from the superior mesenteric artery: a case report.

Aneurysm of the splenic artery which arises from the superior mesenteric artery is a very rare condition with less than twenty cases described in the literature. Most of the time, it is asymptomatic and the diagnosis is fortuitous, but the patient can feel epigastric or left upper quadrant discomfort. One can palpate an abdominal mass or hear an abdominal systolic murmur.

Gastroplasty as a surgical treatment of obesity. Experience of over 400 operations.

Morbid obesity is an illness in itself and causes associated pathologies. Medical and diet treatments being most often ineffective, the surgical alternative has been considered. This study considers a series of 415 patients operated on, at the Bariatric Surgical Centre at the Hospital of Huy, Belgium, from 1983 to 1992.