Publications by authors named "F Laigle-Donadey"
Background: Glioblastoma (GBM) is the most common devastating primary brain cancer in adults. In our clinical practice, median overall survival (mOS) of GBM patients seems increasing over time.
Methods: To address this observation, we have retrospectively analyzed the prognosis of 722 newly diagnosed GBM patients, aged below 70, in good clinical conditions (i.
Objective: The role of surgery in the treatment of malignant gliomas in the elderly is not settled. The authors conducted a randomized trial that compared tumor resection with biopsy only-both followed by standard therapy-in such patients.
Methods: Patients ≥ 70 years of age with a Karnofsky Performance Scale (KPS) score ≥ 50 and presenting with a radiological suspicion of operable glioblastoma (GBM) were randomly assigned between tumor resection and biopsy groups.
Purpose: This study aimed to assess the benefit-risk ratio by determining diagnostic yield and safety of brainstem biopsies in adult patients. The secondary objectives were (i) to compare brainstem biopsy safety and postbiopsy patients' outcomes and survival with those of patients biopsied for a brain or cerebellar lesion, and (ii) to assess the impact of brainstem biopsy on final diagnosis and further therapeutic management.
Methods: Among 1784 stereotactic biopsies performed in adult patients at a tertiary center between April 2009 and October 2020, we retrospectively examined 50 consecutive brainstem biopsies.
Validation of the French version of the Multiple Sclerosis Intimacy and Sexuality Questionnaire 15 Tools which help nurse for assessing the effect of perceived multiple sclerosis symptoms on sexual activity and satisfaction.
Nurs Open
February 2023
Article Synopsis
- - The study aimed to validate a French version of the Multiple Sclerosis Intimacy and Sexuality Questionnaire 15 (MSISQ-15Fr), which assesses how multiple sclerosis symptoms impact sexual activity for patients.
- - Researchers ensured the translation's validity through a thorough process, evaluating its construction, reliability, stability, and reproducibility after having patients complete the survey.
- - The results confirmed that the MSISQ-15Fr is a valid and reliable tool, with strong internal coherence and satisfactory metrics, enabling French-speaking nurses to effectively support sexual health for individuals with multiple sclerosis as endorsed by the World Health Organization.
Objective: New therapeutic approaches are needed to improve the prognosis of glioblastoma (GBM) patients.
Methods: With the objective of identifying alternative oncogenic mechanisms to abnormally activated epidermal growth factor receptor (EGFR) signalling, one of the most common oncogenic mechanisms in GBM, we performed a comparative analysis of gene expression profiles in a series of 54 human GBM samples. We then conducted gain of function as well as genetic and pharmocological inhibition assays in GBM patient-derived cell lines to functionnally validate our finding.