Publications by authors named "F Lager"
Article Synopsis
- Glomeruli are key kidney filtration units dependent on microcirculation, but traditional imaging struggles to accurately measure their blood flow.
- The introduction of sensing Ultrasound Localization Microscopy (sULM) allows for better visualization of kidney structures in 2D, though it has limitations in capturing comprehensive depth information.
- By extending sULM to 3D imaging, this study enhances the ability to analyze glomerular function and assess kidney health, potentially improving diagnostic methods and patient care in clinical settings.
The maternal metabolic environment can be detrimental to the health of the offspring. In a previous work, we showed that maternal high-fat (HH) feeding in rabbit induced sex-dependent metabolic adaptation in the fetus and led to metabolic syndrome in adult offspring. As early development representing a critical window of susceptibility, in the present work we aimed to explore the effects of the HH diet on the oocyte, preimplantation embryo and its microenvironment.
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- * Research conducted on female rodents showed that a single stress event can lead to lasting heart damage, as indicated by changes in blood biomarkers and various imaging techniques.
- * The study highlights that long-term metabolic disruptions in the heart contribute to permanent damage, challenging the idea of Takotsubo being easily reversible and emphasizing the need for early treatment strategies.
Background: Estimation of glomerular function is necessary to diagnose kidney diseases. However, the study of glomeruli in the clinic is currently done indirectly through urine and blood tests. A recent imaging technique called Ultrasound Localization Microscopy (ULM) has appeared.
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