[Mitotic index as a prognostic factor in ductal breast cancer].

150 cases of infiltrating ductal mammary carcinoma with available 8-10 years follow-up data were studied to reveal correlations between mitotic index (MI), pathological mitosis index (PMI), survival after the mastectomy, primary tumor size, histology, degree of cell polymorphism and presence of axillary metastases. It was established that the prognostic value of MI and PMI, and their correlation with other prognostic factors is determined by the stage of tumour progression and histologic type of primary tumour. There is a significant negative correlation between MI, PMI, tumour size and survival in patients surviving maximum 8 years.

[Mitotic regimen of histologic variants infiltrating duct carcinoma of the breast].

Mitotic regimen was studied in 197 cases of infiltrating duct mammary carcinoma found at mammography screening and subdivided according to the prognostic F. Linell classification (1980) into two groups (1-tubular, duct-tubular and II-comedo-type carcinoma). Indices of the mitotic regimen and particularly mitotic index showed statistical differences in these groups.

Primary prognostic factors in invasive breast cancer with special reference to ductal carcinoma and histologic malignancy grade.

Background: In a study of 2290 cases of invasive breast cancer in Malmö, the prognostic value of histologic typing and axillary nodal status was examined. Two periods were studied: Period 1, 1961-1970, and Period 2, 1981-1988.

Methods: All primarily unilateral invasive breast cancers were included in the study and classified according to the histologic classification proposed by Linell et al.

Mastectomy only versus radical mastectomy and postoperative radiotherapy in node negative, resectable breast cancer. A randomized trial.

Patients with clinically node negative resectable breast cancer were randomized to either mastectomy only or radical mastectomy and radiotherapy, and followed for 15-20 years. During follow-up axillary metastases occurred with the same frequency after mastectomy as was initially observed in the group that underwent axillary dissection. There was no significant survival difference between the two groups.

Histopathologic classification of breast cancer in Sweden and Italy: a comparison between two pathologists.

Two large series of breast cancers (BC), identified in the Pathology Departments of Malmö (Sweden) and Florence (Italy), were independently reviewed by two experienced pathologists, one from each department. Overall, comparison of diagnoses of 372 BCs according to a simplified WHO histologic classification system (in four combined categories) revealed agreement for 74% of the cases. Concordance, as measured by the kappa statistic, was relatively good (0.