Publications by authors named "F L Vyas"
Many inherited metabolic disorders (IMD) are associated with end-organ damage necessitating organ transplantation. Although utilization of deceased donors with history of IMD warrants caution, there may be circumstances under which such donors could be considered as suitable organ donor candidates. We present the first known report of liver transplantation from a deceased donor with cystinosis.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) displays a high degree of spatial subtype heterogeneity and co-existence, linked to a diverse microenvironment and worse clinical outcome. However, the underlying mechanisms remain unclear. Here, by combining preclinical models, multi-center clinical, transcriptomic, proteomic, and patient bioimaging data, we identify an interplay between neoplastic intrinsic AP1 transcription factor dichotomy and extrinsic macrophages driving subtype co-existence and an immunosuppressive microenvironment.
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- Understanding how cell fate regulation works in the liver is crucial for improving cell therapies for liver diseases.
- The study highlights the role of TIMP1 and TIMP3 in controlling important proteins (ADAM10 and ADAM17) that activate the NOTCH signaling pathway, impacting liver progenitor cell (LPC) maintenance and cholangiocyte differentiation.
- Loss of TIMP1 and TIMP3 in the liver led to disorganized liver structures, increased collagen buildup, and disrupted Notch signaling, suggesting these proteins play a critical role in liver health and potential therapies.
Solid pseudopapillary neoplasm (SPN) is an unusual tumor of the pancreas. Unlike ductal adenocarcinoma, SPN is commoner in young women and is indolent with better prognosis. Fifteen percent of patients, however, develop metastases, often synchronous and involving the liver or peritoneum.
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- Normothermic regional perfusion (NRP) is a promising method for recovering livers from controlled donation after circulatory death (cDCD) donors, potentially enhancing transplant outcomes and expanding the donor pool in the US, where only 11.4% of deceased donor liver transplants are from cDCD donors.
- This study compared liver transplant outcomes from cDCD donors recovered using NRP versus standard super rapid recovery (SRR) across 17 US transplant centers, focusing on outcomes like ischemic cholangiopathy and post-transplant complications.
- Results showed that livers recovered via NRP had shorter hospital stays (7 days vs. 10 days) and none experienced primary