Spatiotemporal control of kinases and the biomolecular tools to trace activity.

The delicate balance of cell physiology is implicitly tied to the expression and activation of proteins. Post-translational modifications offer a tool to dynamically switch protein activity on and off to orchestrate a wide range of protein-protein interactions to tune signal transduction during cellular homeostasis and pathological responses. There is a growing acknowledgment that subcellular locations of kinases define the spatial network of potential scaffolds, adaptors, and substrates.

Experimentally probing the stability of thin-shell structures under pure bending.

This paper studies the stability of space structures consisting of longitudinal, open-section thin-shells transversely connected by thin rods subjected to a pure bending moment. Localization of deformation, which plays a paramount role in the nonlinear post-buckling regime of these structures and is extremely sensitive to imperfections, is investigated through probing experiments. As the structures are bent, a probe locally displaces the edge of the thin shells, creating local dimple imperfections.

Effective degradation of organophosphate ester flame retardants and plasticizers in coastal sediments under high urban pressure.

Empirical evidence of the effective degradation at environmentally relevant conditions of organophosphate esters (OPEs) flame retardants and plasticizers in coastal sediments from an impacted area in the NW Mediterranean Sea is provided. Half-lives varied from 23.3 to 77.

Synergistic Protection against Secondary Pneumococcal Infection by Human Monoclonal Antibodies Targeting Distinct Epitopes.

persists as a leading cause of bacterial pneumonia despite the widespread use of polysaccharide-based vaccines. The limited serotype coverage of current vaccines has led to increased incidence of nonvaccine serotypes, as well as an increase in antibiotic resistance among these serotypes. Pneumococcal infection often follows a primary viral infection such as influenza virus, which hinders host defense and results in bacterial spread to the lungs.