Publications by authors named "F L Reid"
Introduction: Pelvic organ prolapse (POP) is a common condition, affecting women worldwide and is known to have a significant impact on Health Related Quality of Life (HRQoL). Although there are various treatment options available, including pelvic floor muscle training and support pessaries, many women opt for or require surgery, with a lifetime risk of needing surgery of 12%-19%. As with any operation, this does not come without its complications and the reoperation rate following POP surgery is up to 36%.
View Article and Find Full Text PDFEfficacy and safety of tozorakimab in moderate-to-severe atopic dermatitis: A Phase 2a randomized controlled trial (FRONTIER-2).
J Eur Acad Dermatol Venereol
November 2024
Background: Atopic dermatitis (AD) is a chronic, inflammatory skin disease characterized by intense pruritus and eczematous lesions. Tozorakimab is a high-affinity human monoclonal antibody that neutralizes interleukin-33, a broad-acting alarmin cytokine that is over-expressed in keratinocytes of patients with AD.
Objectives: This Phase 2a study (FRONTIER-2; NCT04212169) evaluated the safety and efficacy of tozorakimab in adults with moderate-to-severe AD.
Article Synopsis
- This study focuses on tozorakimab, an antibody targeting interleukin-33 (IL-33), analyzing how its pharmacokinetics (PK) relate to its target engagement (TE) using data from phase 1 trials.
- The research involved 60 participants receiving varying doses (30-600 mg) of tozorakimab at different frequencies (every 2, 4, or 6 weeks) and utilized simulations to understand its effects on IL-33 levels in the body.
- The findings revealed a strong correlation between the drug's PK and TE, showing that doses over 90 mg effectively inhibited IL-33/sST2 levels, suggesting that the model can help determine optimal dosing for future clinical use
Article Synopsis
- Planned Moon and Mars missions pose greater health risks for astronauts due to constant exposure to space radiation (SR), unlike low Earth orbit missions.
- Studies on female Wistar rats show that exposure to 10 cGy of SR increases risk-taking behavior and slows reaction times, indicating a decline in cognitive processing.
- The study explores whether the effects observed in female rats also apply to other types of space radiation and to male rats, highlighting the need for further research.