Publications by authors named "F L Paz"
Mixed ionic-electronic conductors have great potential as materials for energy storage applications. However, despite their promising properties, only a handful of metal-organic frameworks (MOFs) provide efficient pathways for both ion and electron transport. This work reports a proton-electron dual-conductive MOF based on tetrathiafulvalene(TTF)-phosphonate linkers and lanthanum ions.
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- - Alzheimer's disease leads to cognitive decline and memory loss, linked to issues with the neurotransmitter acetylcholine, prompting interest in developing effective acetylcholinesterase (AChE) inhibitors.
- - New thiazoloindazole-based compounds have shown potential as AChE inhibitors, with some outperforming the existing treatment drug donepezil in molecular studies, and good synthesis yields of 66 to 87%.
- - The most promising derivatives feature a bis(trifluoromethyl)phenyl-triazolyl group, which effectively inhibits AChE, achieving remarkable inhibitor potency with an IC value below 1.0 μM.
An optimization of the pyridylpiperazine series against Plasmodium falciparum has been performed, exploring a structure-activity relationship carried out on the toluyl fragment of hit 1, a compound with low micromolar activity against Plasmodium falciparum discovered by high-throughput screening. After confirming the crucial role played by this aryl fragment in the antiplasmodial activity, the replacement of the ortho-methyl substituent of 1 by halogenated ones led to an improvement for four analogs, either in terms of potency, expected pharmacokinetics profile, or both. Further introduction of endocyclic nitrogens in this fragment identified two more optimized compounds, 20 and 23, which are expected to be much more metabolically stable than 1.
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- A new multicomponent metal-organic radical framework was developed, combining luminescent and non-emissive organic linkers with Zn(II) ions, featuring a layered structure with microporous channels.
- This framework retains its luminescence at room temperature and introduces additional magnetic and electrochemical properties, highlighting the potential for designing advanced materials with adjustable properties using different organic linkers.