Publications by authors named "F L Ndlandla"

Article Synopsis
  • * Researchers created chicken-derived antibodies (scFv) that could react to these different types of MA and tested their ability to cross-react with cholesterol.
  • * The study found that certain antibody configurations showed weak cross-reactivity with cholesterol, particularly those recognizing trans-keto MA, suggesting these antibodies could be useful for diagnosing tuberculosis.
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Mycobacterium tuberculosis, the causative agent of tuberculosis, is characterized by the abundance of species specific, antigenic cell wall lipids called mycolic acids. These wax-like molecules all share an identical, amphiphilic mycolic motif, but have different functional groups in a long hydrophobic hydrocarbon mero-chain that divide them into three main classes: alpha-, keto- and methoxy-mycolic acids. Whereas alpha-mycolic acids constitutively maintain an abundance of around 50%, the ratio of methoxy- to keto-mycolic acid types may vary depending on, among other things, the growth stage of M.

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