Serum lipid profiling reveals characteristic lipid signatures associated with stroke in patients with leukoaraiosis.

Many lipid biomarkers of stroke have been identified, but the lipid metabolism in elderly patients with leukoaraiosis remains poorly understood. This study aims to explore lipid metabolic processes in stroke among leukoaraiosis patients, which could provide valuable insights for guiding future antithrombotic therapy. In a cohort of 215 individuals undergoing MRI, 13 stroke patients were matched with controls, and 48 stroke patients with leukoaraiosis were matched with 40 leukoaraiosis patients.

Application of Fourier transform infrared spectroscopy to exhaled breath analysis for detecting helicobacter pylori infection.

Helicobacter pylori (H. pylori) is one of the most globally prevalent bacteria, closely associated with gastrointestinal diseases such as gastric ulcers and chronic gastritis. Current clinical methods primarily involve Carbon-13 and Carbon-14 urea breath test, both carrying potential safety risks.

Efficient electrochemiluminescence sensor utilizing Zr-PyTCPPMOF for swift hydrogen sulfide detection.

The ultrahigh-sensitive detection of HS is reported using a novel dual-ligand metal-organic framework (MOF) electrochemiluminescence (ECL) sensor. By combining tetrakis(4-carboxyphenyl) porphyrin (TCPP) and 1,3,6,8-tetrakis(4-carboxyphenyl) pyrene (TBAPy) as ligands and employing zirconium as the metal source, a spindle-shaped Zr-PyTCPPMOF was successfully designed and synthesized. Notably, the multiple nitrogen structures of porphyrin provided abundant binding sites for sulfur (S), further enhancing the ECL signal of Zr-PyTCPPMOF.

Fucoxanthin ameliorates ulcerative colitis by maintaining the epithelial barrier via blocking JAK2/STAT3 signaling pathway.

Background: The clinical efficacies of Ulcerative colitis (UC) are far from satisfactory. Fucoxanthin (FUC) is a marine carotenoid that is abundant in seaweed and microalgae. It has been reported that FUC can possess anti-inflammatory and antioxidant.

Irisin reprograms microglia through activation of STAT6 and prevents cognitive dysfunction after surgery in mice.

Postoperative cognitive dysfunction (POCD) is common in the aged population and associated with poor clinical outcomes. Irisin, an endogenous molecule that mediates the beneficial effects of exercise, has shown neuroprotective potential in several models of neurological diseases. Here we show that preoperative serum level of irisin is reduced in dementia patients over the age of 70.