Biomarkers.

Background: The exact impacts of β-site APP cleaving enzyme (BACE1) on brain atrophy and cognitive decline in the Alzheimer's disease (AD) remain not fully understood. This study aimed to investigate the relationship between BACE1 in cerebrospinal fluid (CSF) and amyloid-β (Aβ) pathology, neurodegeneration and cognitive function.

Method: This study involved 359 participants from original individuals of the China Aging and Neurodegenerative Disorder Initiative (CANDI) cohort, who underwent measurements of AD biomarkers.

Spinal tissue identification using a Forward-oriented endoscopic ultrasound technique.

The limited imaging depth of optical endoscope restrains the identification of tissues under surface during the minimally invasive spine surgery (MISS), thus increasing the risk of critical tissue damage. This study is proposed to improve the accuracy and effectiveness of automatic spinal soft tissue identification using a forward-oriented ultrasound endoscopic system. Total 758 ex-vivo soft tissue samples were collected from ovine spines to create a dataset with four categories including spinal cord, nucleus pulposus, adipose tissue, and nerve root.

Pathological angiogenesis was associated with cerebrovascular lesion and neurodegeneration in Alzheimer's disease.

Introduction: We investigated the specific factors driving abnormal angiogenesis in Alzheimer's disease (AD) and its role in cerebrovascular lesions and neurodegeneration.

Methods: We assessed cerebrovascular pathologies, amyloid-beta (Aβ), and tau pathologies in post mortem human brains and detected 12 angiogenic factors in cerebrospinal fluid (CSF) from the China Aging and Neurodegenerative Disease Initiative (CANDI) cohort.

Results: We observed severe blood-brain barrier damage and elevated levels of the vascular marker CD31 in human AD brains, which had a stronger correlation with tau pathology than Aβ pathology.

HCG18 Promotes Cell Proliferation and Stemness in Cholangiocarcinoma via the miR-194-5p/KRT18/MAPK Signaling.

Accumulating evidence has demonstrated that Keratin18 (KRT18) functions as a pivotal gene in the progression of various cancers. However, its role in cholangiocarcinoma (CCA) remains unexplored. Our study elucidated the biological functions and underlying mechanisms of KRT18 in CCA.

Correlation between low testosterone levels and the risk of osteoarthritis: a cross-sectional analysis of NHANES data (2011-2016).

Background: Osteoarthritis (OA) is a common degenerative joint disease that significantly impacts the quality of life, especially among older adults. Testosterone, a critical hormone for musculoskeletal health, has been suggested to influence OA pathogenesis. However, the relationship between low testosterone levels and OA risk remains underexplored in large, representative populations.