Publications by authors named "F Kuehnel"
Unlabelled: Hepatitis C virus (HCV) efficiently infects only humans and chimpanzees. Although the detailed mechanisms responsible for this narrow species tropism remain elusive, recent evidence has shown that murine innate immune responses efficiently suppress HCV replication. Therefore, poor adaptation of HCV to evade and/or counteract innate immune responses may prevent HCV replication in mice.
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- Only humans and chimpanzees are capable of chronic hepatitis C virus (HCV) infections, and the virus's restricted ability to affect other species is related to specific host requirements during its life cycle.
- Researchers created mouse liver-derived cell lines with altered immune responses to study HCV replication, discovering that reduced immune reaction and the addition of human microRNA 122 (miR-122) significantly enhance HCV RNA replication.
- By expressing human entry cofactors and certain proteins, these modified mouse cells can successfully replicate HCV, indicating that all stages of the virus's life cycle can be recreated in these cells for research purposes.
Background: Common marmosets (Callithrix jacchus) are susceptible to gastrointestinal diseases. Sensitivity to nutritional elements, for example gluten, has been suggested, but a serological screening has not been performed yet.
Methods: A gluten-containing diet was offered to 24 animals, followed by a gluten-free diet.
Article Synopsis
- Autoimmune hepatitis (AIH) is a chronic liver disease that can lead to cirrhosis if untreated, and most patients require lifelong immunosuppression to manage it, though this can come with significant side effects.
- A new experimental murine model of AIH was created using an adenoviral infection that mimics the disease progression seen in humans, highlighting the importance of both genetic predisposition and environmental triggers.
- This model has identified critical immune mechanisms involved in AIH and has shown that treatments like prednisolone and budesonide can be effective, paving the way for testing new therapies that may have fewer side effects.
Common marmosets are suitable non-human primate models for many human diseases. Standard values for blood parameters are required to evaluate physiological and pathological situations. Two studies were conducted: study I to determine standard values and study II to examine these under changed housing conditions.
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