Publications by authors named "F Krenzien"
Introduction: Synchronous liver metastases occur in approximately 15-20% of patients with colorectal cancer. Optimal oncological treatment of oligometastatic disease combines surgical resection and systemic therapy. Open simultaneous resection of the primary and liver metastases is well described, but there is not much evidence for the increasing use of the minimally invasive approach.
View Article and Find Full Text PDFPurpose: Median arcuate ligament syndrome (MALS) is a rare disorder caused by compression of the celiac artery (CA) by the median arcuate ligament (MAL). Common symptoms include postprandial abdominal pain, diarrhea, and weight loss. While laparoscopic MAL division has long been considered the procedure of choice, robotic-assisted procedures have been increasingly used since their introduction.
View Article and Find Full Text PDFArticle Synopsis
- Multimodal two-stage hepatectomy (mTSH) is a surgical approach for patients with bilobar colorectal liver metastases (CRLM) who can't be treated with a single operation due to limited liver function.
- A narrative review of clinical studies shows that interval chemotherapy is used in mTSH and might improve disease control, though only a few studies have specifically reported its effects.
- Current data suggest that interval chemotherapy does not negatively impact liver growth during mTSH or lead to serious complications, but more randomized clinical trials are needed for definitive conclusions.
Background: Intrahepatic cholangiocarcinoma (ICC) is a disease with poor prognosis and limited therapeutic options. We investigated the tumor immune microenvironment (TIME) to identify predictors of disease outcome and to explore targets for therapeutic modulation.
Methods: Liver tissue samples were collected during 2008-2019 from patients ( = 139) diagnosed with ICC who underwent curative intent surgery without neoadjuvant chemotherapy.