Publications by authors named "F Krause"
Inorganic nitrate (NO) has been proposed to be of therapeutic use as a dietary supplement in obesity and related conditions including the Metabolic Syndrome (MetS), type-II diabetes and metabolic dysfunction associated steatotic liver disease (MASLD). Administration of NO to endothelial nitric oxide synthase-deficient mice reversed aspects of MetS, however the impact of NO supplementation in diet-induced obesity is not well understood. Here we investigated the whole-body metabolic phenotype and cardiac and hepatic metabolism in mice fed a high-fat high-sucrose (HFHS) diet for up to 12-months of age, supplemented with 1 mM NaNO (or NaCl) in their drinking water.
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- - The paper explores how Knowledge Graphs (KGs) can facilitate real-time human interventions in AI-driven manufacturing processes in the evolving Industry 5.0 environment to enhance system performance under dynamic conditions.
- - It advocates for a "late shaping" design approach, allowing for adaptability and integration of human intelligence during runtime, contrasting with the traditional "early shaping" method that fixes system behavior at the design phase.
- - The discussion includes insights from the European project Teaming.AI, focusing on challenges such as domain expertise modeling, vertical knowledge integration, and dynamically populating KGs for improved relational machine learning outcomes.
Background And Purpose: Critical illness polyneuropathy (CIP) has been linked to neurocardiac dysfunction mediated by autonomic nervous system dysregulation, which increases mortality. We aimed to assess if heart rate variability (HRV) biofeedback could improve neurocardiac function in CIP.
Methods: We randomly allocated (1:1) patients with electrophysiologically confirmed CIP undergoing early inpatient neurological rehabilitation to additional HRV or sham biofeedback over 14 days.
Gut microbiota-derived metabolites play a pivotal role in the maintenance of intestinal immune homeostasis. Here, we demonstrate that the human commensal possesses a specific metabolic fingerprint, consisting predominantly of the tryptophan catabolite indole-3-propionic acid (IPA), the branched-chain acids (BCFAs) isobutyrate and isovalerate and the short-chain fatty acids (SCFAs) acetate and propionate. Mono-colonization of germ-free mice with (CS mice) affected colonic mucosal immune cell phenotypes, including up-regulation of gene expression, and increased abundance of transcriptionally active colonic tuft cells and Foxp3 regulatory T cells (Tregs).
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