Publications by authors named "F Kramar"
Article Synopsis
- Glioblastoma is the most common and aggressive primary brain tumor, making diagnosis difficult due to its genetic variability and poor prognosis.
- A complex case study utilized multiple cytogenomic methods to identify key genetic markers, revealing classical glioblastoma characteristics and distinct pathological clones.
- The study suggests an integrated approach for diagnosis, focusing on detecting genetic alterations to potentially improve patient outcomes in terms of diagnosis, prognosis, and treatment predictions.
Article Synopsis
- Fibroblast activation protein (FAP) is often found in tumors, particularly glioblastomas, and contributes to a supportive environment for tumor growth, often located near activated blood vessel cells.
- FAP mesenchymal cells in glioblastomas do not initiate tumors themselves but can enhance blood vessel formation (angiogenesis) and assist in the movement and growth of glioma cells through signaling mechanisms.
- The study indicates that FAP mesenchymal cells have a distinct profile of signaling factors that promote angiogenesis and may aid in the worsening of glioblastoma progression, making them a potential target for therapies.
Malignant transformation in gliomas is frequently supplemented by somatic mutations in isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 genes. It has recently emerged that mutations in these genes are associated with prolonged survival and should be used as prognostic factor in management of brain cancer patients. There are several approaches in use for the detection of isocitrate dehydrogenase 1 and 2 mutations; however, these often exhibit shortcomings such as convoluted protocols with long processing time, complex (and costly) dedicated fluorescent probes, and/or demand on amounts of input DNA.
View Article and Find Full Text PDFGliomas are a heterogeneous group of tumours varying in prognosis, treatment approach, and overall survival. Recently, novel markers have been identified which are linked to patient prognosis and therapeutic response. Especially the mutation of the enzyme isocitrate dehydrogenase 1 or 2 (IDH1/2) gene and the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status seem to be the most important predictors of survival.
View Article and Find Full Text PDFBackground: Diffuse astrocytomas are characterized by their highly variable biological behavior. The possibility that tumors develop novel aberrations, with relevant biological properties, is often neglected. In this study, we present two cases of diffuse astrocytoma in which additional cytogenetic and epigenetic markers with potential influence on cell proliferation or differentiation were detected at relapse.
View Article and Find Full Text PDF