Publications by authors named "F Korchi"
Objective: Our case-control study aimed to access the potential association of insertion/deletion (I/D) ACE (angiotensin converting enzyme) gene polymorphism with myocardial infarction (MI) risk of occurrence among a sample of Moroccan patients, especially young ones.
Results: Distribution of I/D ACE gene variant among cases vs controls, showed that healthy controls carried out higher frequency of wild type allele I compared to cases (23.5% vs 21.
Coagulation factor Leiden mutation has been described as a common genetic risk factor for venous thrombosis; however, this mutation was reported to be practically absent in an African population. Recently, a novel non-sense mutation in the gene encoding factor V has been associated with the risk of occurrence of cardio-cerebrovascular diseases such as stroke and venous thrombosis. The aim of the present study was to investigate whether the factor V Leiden (FVL) and C2491T non-sense mutations are associated with the risk of developing myocardial infarction.
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- Myocardial infarction (MI) is a major cause of death globally, linked to both genetic and environmental factors.
- This study examined the connections between specific genetic polymorphisms (C677T and prothrombin) and the risk of developing MI in 100 patients versus 182 healthy individuals.
- Results indicated a significant association of the prothrombin polymorphism with increased MI risk, suggesting it could serve as a genetic marker, while no link was found for the C677T polymorphism, highlighting the multifactorial nature of MI.
Background: Myocardial infarction (MI) is a common multifactorial disease. Numerous studies have found that genetic plays an essential role in MI occurrence. The main objective of our case-control study is to explore the association of G894T eNOS (rs1799983), 4G/5G PAI (rs1799889) and T1131C APOA5 (rs662799) polymorphisms with MI susceptibility in the Moroccan population.
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- * The study involved 101 patients with hypertension and 102 healthy controls, utilizing genetic analysis methods to assess the MTHFR C677T genotypes, finding a significant association between the mutant 677TT genotype and increased hypertension risk.
- * The results indicated that having the homozygous 677TT variant was linked to a higher likelihood of developing hypertension, particularly in those with a family history of heart disease, suggesting the need for larger studies to validate these findings.