Publications by authors named "F Klevebro"
Curative treatment for oligometastatic gastroesophageal cancer- results of a prospective multicenter study.
Langenbecks Arch Surg
December 2024
Purpose: Oligometastatic gastroesophageal cancer is a clinical entity with no standard treatment recommendation. Treatment with curative intent has recently emerged as an option for selected patients in contrast to the traditional palliative treatment strategy. This prospective study aimed to assess the safety and efficacy of combined systemic and local treatment with curative intent for patients with oligometastatic gastroesophageal cancer.
View Article and Find Full Text PDFBackground/aims: This study aimed to clarify the risk of progression in patients with non-dysplastic Barrett's esophagus (NDBE) and patients with confirmed low-grade dysplasia (LGD) and indefinite for dysplasia (IND) after an expert pathologist review of patients with BE with suspected dysplasia in a prospective cohort.
Methods: Patients with Barrett's esophagus diagnosed with dysplasia at Ersta Hospital in Stockholm from 1998 to 2012 were included. The first dysplastic specimen in all patients was re-evaluated by two expert pathologists and classified as NDBE, LGD, IND, or cancer, including high-grade dysplasia.
Article Synopsis
- This study aimed to explore the impact of chronic obstructive pulmonary disease (COPD) on the risk of postoperative complications after pancreatoduodenectomy, a surgery for pancreatic cancer.
- Of 1009 patients studied, 57 had COPD, but no significant link was found between COPD and major complications as assessed by the Clavien-Dindo score (CD≥ IIIa). However, COPD was linked to a higher risk of developing postoperative pancreatic fistula (POPF).
- The findings suggest that while COPD does not increase overall complication rates significantly, it does pose a higher risk for POPF, indicating the need for careful evaluation of COPD in surgical risk assessments.
Objective: To evaluate outcomes after primary surgery (PS) or neoadjuvant treatment followed by surgery (NAT/S) in cT2 staged adenocarcinomas of the esophagus (EAC) and gastroesophageal junction (GEJ), a multinational high-volume center study was undertaken.
Background: The optimal treatment approach with either NAT/S or PS for clinically staged cT2cN any or cT2N0 EAC and GEJ remains unknown due to the lack of randomized controlled trials.
Methods: A retrospective analysis of prospectively maintained databases from 10 centers was performed.
Importance: The prognosis of patients with adenocarcinoma of the esophagus and esophagogastric junction (AEG) is poor. From current evidence, it remains unclear to what extent preoperative chemoradiotherapy (CRT) or preoperative and/or perioperative chemotherapy achieve better outcomes than surgery alone.
Objective: To assess the association of preoperative CRT and preoperative and/or perioperative chemotherapy in patients with AEG with overall survival and other outcomes.