[Change in hemoproteid metabolism and its importance in the development of disorders of detoxication processes in patients with iron-deficiency anemia].

The study has been carried out to find out the value of disorders of heme synthesis and heme disintegration processes taking place in liver in patients with iron-deficiency anemia as well as in connection with the activity of detoxication enzymes.

[Activity of heme synthesis enzymes in the bone marrow cells of rats with alimentary iron-deficient anemia].

An intensification of aminolevulinic acid (ALA)-synthase on the day of experiment and its tend to its further gradual inhibition noted to be in the bone marrow cells of rats with alimentary iron-deficient anemia (IDA). An activity of porfobilinogen (PB)-synthase was increasing in all the terms of the trial, that of ferrochelatase--on the day 10, and it was inhibited later on. Such changes in an activity of heme synthesis key enzymes result in an accumulation of intermittent products.

[Differential and diagnostic informative criteria of chronic virus hepatitis D in children].

The comparison of clinical and laboratory analyses of HVGD and HVGV gave very informative diagnostic and clinical features in diagnostics of these conditions. They are the following: syndrome of endogenous intoxication, laboratorial data indicating high sensibility to delta antigen, increase in immune cellular value (SD4+, SD8+) and intensity of endogenous intoxication syndrome.

[Lymphocyte subpopulation changes in children with chronic virus hepatitis D and B].

We observed 367 children with chronic viral hepatitis Delta (CVHD) and B (CVHB) and found strict secondary T-immunodeficiency, more expressed in children with CVHD. We have found also the most characterizing changes of lymphocytes subpopulation and natural killer-cells depending on etiology of CVH. As for CVHD it is characterized by more significant decrease in CD4-lymphocytes, as for CVHB--CD8-lymphocytes.