Publications by authors named "F Kevin Walters"

Article Synopsis
  • - Niemann-Pick type C disease is caused mainly by mutations in the NPC1 gene, leading to cholesterol buildup and lysosomal dysfunction.
  • - The study tested polyphenol-rich extracts from *L.* (RCME) and its components, rutin and quercitrin, to see if they could improve NPC1 protein trafficking and reduce cholesterol levels in NPC patient-derived fibroblasts, finding that RCME was effective while the drug miglustat was not.
  • - RCME was shown to improve the trafficking of various NPC1 mutants and lower cholesterol levels, suggesting it may be a more effective therapeutic option than current treatments that only reduce cholesterol levels.
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Purpose Of Review: This review defines intersectionality, discusses recent studies that use an intersectional framework in adolescent health research, and outlines ways where clinicians can use intersectionality to address health disparities in youth of color through clinical practice, research, and advocacy.

Recent Findings: Research using an intersectional framework can identify populations at risk for certain disorders or behaviors. Recent studies in adolescent health research using an intersectional lens identified lesbian girls of color as an at-risk population for e-cigarette use, demonstrated lower skin color satisfaction among Black girls of all ages predicted greater binge-eating disorder symptoms, and showed that two-thirds of Latine (gender-neutral term that refers to people with Latin American roots) youth who recently immigrated to the United States experienced at least one traumatic event during their migration journey, putting them at risk for PTSD and other mental health disorders.

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The current contents of visual working memory can be disrupted by previously formed memories. This phenomenon is known as proactive interference, and it can be used to index the availability of old memories. However, there is uncertainty about the robustness and lifetime of proactive interference, which raises important questions about the role of temporal factors in forgetting.

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Background: The novel nature of the coronavirus disease 2019 (COVID-19) pandemic places challenges on nursing students as they try to complete the clinical requirement of their training. Nursing faculties need to understand these challenges to support and equip nursing students to enter the workforce.

Aim: To explore and describe the anticipated and subsequent perceptions of final year Bachelor of Nursing students returning to clinical practice during the COVID-19 pandemic in South Africa.

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Microglia are the resident immune cell of the brain involved in the development and progression of Alzheimer's disease (AD). Modulation of microglia activity represents a potential mechanism for treating AD. Herein, the compound NNC 26-9100 (NNC) was evaluated in toxicity, nitric oxide release, Aβ1-42 uptake and cytosolic calcium assays during lipopolysaccharide (LPS)-activated conditions using mouse BV2 microglia cells.

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