We report on the nonlinear temporal post-compression of 7 mJ sub-40 fs pulses from a commercial kHz Ti:sapphire laser down to a record 3.8 fs duration (sub-1.5 optical cycle) in a compact single-stage gas-filled multi-pass cell (MPC), with 60% overall compression efficiency.
View Article and Find Full Text PDFMulti-pass cell (MPC) compressors have proven to be the method of choice for compression of high average power long-pulse Yb lasers. Yet, generating sub-30 fs pulses at high pulse energy with compact and simple components remains a challenge. This work demonstrates an efficient and cost-effective approach for nonlinear pulse compression at high pulse energy using a hybrid air-bulk MPC.
View Article and Find Full Text PDFRespiratory syncytial virus (RSV) is a significant threat to elderly populations and repeated infections that occur throughout life are poorly protective. To assess the role of prior RSV infections as well as elderly immune senescence on vaccine efficacy, we compared immune responses after virus-like particle (VLP) immunization of elderly cotton rats and young cotton rats, both previously RSV infected, in order to mimic the human population. We show that immunization of RSV-experienced young or elderly animals resulted in the same levels of anti-pre-F IgG, anti-G IgG, neutralizing antibody titers, and protection from challenge indicating that the delivery of F and G proteins in a VLP is equally effective in activation of protective responses in both elderly and young populations.
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