Publications by authors named "F Katsuoka"
Purpose: To explore the frequency and positions of genetic mutations in CYP1B1 and FOXC1 in a Japanese population.
Study Design: Molecular genetic analysis.
Methods: Genomic DNA was extracted from 31 Japanese patients with childhood glaucoma (CG) from 29 families.
Oxygen is critical for all metazoan organisms on the earth and impacts various biological processes in physiological and pathological conditions. While oxygen-sensing systems inducing acute hypoxic responses, including the hypoxia-inducible factor pathway, have been identified, those operating in prolonged hypoxia remain to be elucidated. Here we show that pyridoxine 5'-phosphate oxidase (PNPO), which catalyses bioactivation of vitamin B6, serves as an oxygen sensor and regulates lysosomal activity in macrophages.
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- Whole blood transcriptome analysis offers valuable insights for medical research, primarily due to easy sample collection and the detailed information it provides about gene expression influenced by factors like age and gender.
- A study was conducted on 576 participants from the Tohoku Medical Megabank, stratifying by age (20-30s and 60-70s) and gender, including pregnant women, to analyze RNA sequencing data and investigate gene expression differences.
- Findings revealed associations between gene expression and age/gender differences, as well as the impact of immune response status (neutrophil-to-lymphocyte ratio) on gene diversity, resulting in a significant data set for future research in the Japanese population.
Background: In the TSUBAKI study, bardoxolone methyl significantly increased measured and estimated glomerular filtration rates (GFR) in patients with multiple forms of chronic kidney disease (CKD), including Japanese patients with type 2 diabetes and stage 3-4 CKD. Since bardoxolone methyl targets the nuclear factor erythroid 2-related factor 2 pathway, this exploratory analysis of the TSUBAKI study investigated the impact of the regulatory single nucleotide polymorphism, rs6721961, on the effects of bardoxolone methyl.
Methods: Japanese patients aged 20-79 years with type 2 diabetes and stage 3-4 CKD were randomized to bardoxolone methyl 5-15 mg/day (titrated as tolerated) or placebo for 16 weeks.