Publications by authors named "F Karagianni"
Article Synopsis
- * The combination of Ruxolitinib (a JAK inhibitor) and Resminostat (an HDAC inhibitor) has shown promising results in reducing tumor cell migration and angiogenesis in experimental models of cutaneous T-cell lymphoma (CTCL).
- * Treatment with these inhibitors resulted in a significant decrease in the migration of CTCL cells and blood vessel formation, indicating their potential as effective anti-angiogenic therapies for improving treatment strategies in CTCL.
Gallstone ileus is a relatively rare complication of cholelithiasis, and an uncommon cause of small bowel obstruction most commonly seen in elderly and debilitated people with associated comorbidities. Symptoms of gallstone ileus are insidious and may be vague while the delay in diagnosis results in a high mortality rate. Herein we report two cases of gallstone ileus in elderly patients with complex medical history who presented at the emergency department with abdominal pain and distension, vomiting and fluid/electrolyte disorders due to cholecysto-enteric fistula and bowel obstruction.
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- Retroperitoneal abscesses are rare but serious infections in the abdomen that can be difficult to diagnose due to vague symptoms.
- The condition can lead to severe health complications if not identified and treated promptly.
- The case presented involves a 32-year-old intravenous drug user who developed a retroperitoneal abscess after injecting drugs into a vein, experiencing high fever, hiccups, and back pain as primary symptoms.
Psoriasis may affect patients' sleep. In order to examine this relationship, this study evaluated non-anxious and non-depressive patients with moderate to severe psoriasis before and after 6 months of systemic treatment. A prospective case-control study with 46 consecutive patients (mean age 51.
View Article and Find Full Text PDFThe combination of Resminostat (HDACi) and Ruxolitinib (JAKi) exerted cytotoxic effects and inhibited proliferation of CTCL cell lines (MyLa, SeAx) in previously published work. A xenograft tumor formation was produced by implanting the MyLa or SeAx cells on top of the chick embryo chorioallantoic membrane (CAM). The CAM assay protocol was developed to monitor the metastatic properties of CTCL cells and the effects of Resminostat and/or Ruxolitinib in vivo.
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