Publications by authors named "F KOENIG"
We present a single-arm, phase II, neoadjuvant trial with the oncolytic virus talimogene laherparepvec (T-VEC) in 18 patients with difficult-to-resect cutaneous basal cell carcinomas. The primary end point, defined as the proportion of patients, who after six cycles of T-VEC (13 weeks), become resectable without the need for plastic reconstructive surgery, was already achieved after stage I (9 of 18 patients; 50.0%); thus the study was discontinued for early success.
View Article and Find Full Text PDFA general consonance principle for closure tests based on -values.
Stat Methods Med Res
September 2024
Article Synopsis
- The closure principle is a method for creating testing procedures that effectively control the familywise error rate, particularly when dealing with independent hypotheses and closed tests.
- Various combination tests like Fisher, Stouffer, and Omnibus are used for testing intersection hypotheses, but some do not always guarantee consistent results when the global null hypothesis is rejected.
- The authors propose a general method to enhance closed tests by adjusting rejection regions to ensure consistency, demonstrating through simulations that this can significantly boost the power of tests like Fisher and Stouffer.
Perfusion Patterns of Peripheral Pulmonary Metastasis Using Contrast-Enhanced Ultrasound (CEUS) and Their Correlation with Immunohistochemically Detected Vascularization Pattern.
Cancers (Basel)
October 2024
Purpose: Description of the perfusion of pulmonary metastasis by contrast-enhanced ultrasound (CEUS) and their correlation with vascularization patterns represented by immunohistochemical CD34 endothelial staining.
Patients And Methods: The data of 54 patients with histologic proven peripheral pulmonary metastasis, investigated between 2004 and 2023 by CEUS. These CEUS parameters were evaluated: time to enhancement (TE), categorized as early pulmonary-arterial (PA) or delayed bronchial-arterial (BA) patterns; extent of enhancement (EE), either marked or reduced; homogeneity of enhancement (HE), homogeneous or inhomogeneous; and decrease of enhancement (DE), rapid washout (<120 s) or late washout (≥120 s).
Article Synopsis
- The study aimed to compare the effectiveness of measuring intraepidermal nerve fiber density (IENFD) from skin biopsies and confocal corneal microscopy (CCM) in diagnosing distal symmetric polyneuropathy (DSP) and small fiber neuropathy (SFN) among obese participants.
- Results showed that distal leg IENFD had the highest diagnostic capability for both conditions, while CCM showed poorer performance, and most participants expressed a preference for skin biopsies over the corneal test.
- The Michigan Neuropathy Screening Instrument (MNSIq) demonstrated diagnostic abilities similar to distal leg IENFD, highlighting its potential utility in clinical diagnosis of DSP and SFN. *
Introduction: Heterotopic ossifications (HOs) are a well-known complication following total hip arthroplasty. Yet only little is known about the development of HOs following a femoral fracture and intramedullary stabilization in polytraumatized patients. Thus, the present study aimed to investigate whether the development of HOs is being observed more frequently in patients suffering polytrauma compared to those with single-extremity trauma.
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