[New approaches to the drug prophylaxis of mammary tumor: evaluation of the prophylactic effect of lovastatin and captopril in rats with experimental mammary gland tumors].

Effects of the GABA-CoA reductase inhibitor lovastatin and the ACE inhibitor captopril on the induction and growth of mammary gland tumors induced by N-methyl-N-nitrosourea in Wistar rats have been studied. It is established that lovastatin administered in a doze of 80 mg/kg two times a week exhibits anticarcinogenic activity, which is manifested by a significant decrease in the incidence of neoplasms and an increase in the survival lifetime in the experimental animals. Captopril administered in a doze of 50 mg/kg two times a week significantly decreased the tumor growth rate.

Effects of acetylsalicylic acid and celecoxib on the N-nitrosodiethylamine induced carcinogenesis in rat liver and esophagus.

The effects of nonsteroid antiinflammatory drugs (acetylsalicylic acid and celecoxib) on N-nitrosodiethylamine-induced carcinogenesis in the liver and esophagus were studied in rats. The inhibitory effect of celecoxib on carcinogenesis was more pronounced (in comparison with acetylsalicylic acid), which manifested in a significantly decreased incidence of neoplastic changes in the liver tissue (from 91.7 to 65.

[Study of the role of the feeding factor in the development of induced experimental mammary cancer in rats].

It is studied the influence of two types of experimental diets on rats origin mammary tumors. The first diet was enriched by pig's fat and 2nd diet contained soybean protein and induced N-nitrozo-N-methylurea (MNM). The tumors of rat's mamma were induced by intramammary injections of N-nitrozo-N-methylurea in area of the 2nd left mamma in dose 2.

[Prevention using ascorbic acid, hexamethylenetetramine and sodium metabisulfite of the blastomogenic effect caused by the combined administration into the stomach of mice of sodium nitrite with methylurea or with aminopyrine].

It was shown in experiments on 186 mice that formation of tumors of the lung and fore-stomach induced by injection of sodium nitrite in combination with aminopyrine or methylurea is inhibited following treatment with ascorbic acid, hexamethylenetetramine or sodium metabisulfite.

[Effect of glucuronic acid on the carcinogenic action of urethane, dibutylnitrosamine and 7,12-dimethyl[A]anthracene].

C57W and SHR mice were given intraperitoneal injections of 100 or 300 mg/kg body weight glucuronic acid (in isotonic NaCl solution) 15-30 minutes prior to treatment with urethan, dibutylnitrosamine or 7,12-dimethyl-1,2-benzanthracene. This resulted in a lower carcinogenic effect on the lung and the incidence of lung adenoma was half that registered in the animals who had received a carcinogen only.