Publications by authors named "F Jonasson"
Age-related macular degeneration (AMD) is one of the most common causes of visual impairment in the elderly, with a complex and still poorly understood etiology. Whole-genome association studies have discovered 34 genomic regions associated with AMD. However, the genes and cognate proteins that mediate the risk, are largely unknown.
View Article and Find Full Text PDFArticle Synopsis
- The study examined whether body size at birth, such as weight and length, is linked to the development of age-related macular degeneration (AMD) in older adults aged 67-89 years.
- It involved 1497 participants and included data from birth records and retinal health assessments taken five years apart, using regression analyses to account for various confounding factors.
- Findings showed no consistent relationship between birth size and AMD, although a higher prevalence was noted in individuals who were larger at birth and obese in old age, indicating some unidentified factors may be influencing these trends.
Article Synopsis
- Lp(a) is a risk factor for cardiovascular diseases, with its molar concentration being more significant than apo(a) size in contributing to this risk.
- A study involving over 143,000 Icelanders found that higher Lp(a) levels are linked to various cardiovascular conditions, while low levels may increase the risk of type 2 diabetes (T2D).
- Reducing Lp(a) levels in individuals with the highest concentrations could potentially lower coronary artery disease (CAD) risk without raising the risk of T2D.
The corneal endothelium is vital for transparency and proper hydration of the cornea. Here, we conduct a genome-wide association study of corneal endothelial cell density (cells/mm), coefficient of cell size variation (CV), percentage of hexagonal cells (HEX) and central corneal thickness (CCT) in 6,125 Icelanders and find associations at 10 loci, including 7 novel. We assess the effects of these variants on various ocular biomechanics such as corneal hysteresis (CH), as well as eye diseases such as glaucoma and corneal dystrophies.
View Article and Find Full Text PDFBackground: Lipids are implicated in the pathogenesis of age-related macular degeneration (AMD). The relationship between systemic lipids and AMD has not been well characterized. The objective was to investigate the relationship between serum lipids and AMD in older adults using a lipidomic approach.
View Article and Find Full Text PDF