Publications by authors named "F Javier Aguado"

High-charge micas exhibit improved adsorption properties and are a promising alternative clay material for the engineered barrier in deep geological repositories. When combined with Eu cations, they serve as an in situ luminescent probe for tracking the physical-chemical changes occurring in this engineered barrier over the long term. Therefore, a better understanding of the local environment of the lanthanide is highly desirable to comprehend the specific behavior of these systems.

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Homologous recombination involves the formation of branched DNA molecules that may interfere with chromosome segregation. To resolve these persistent joint molecules, cells rely on the activation of structure-selective endonucleases (SSEs) during the late stages of the cell cycle. However, the premature activation of SSEs compromises genome integrity, due to untimely processing of replication and/or recombination intermediates.

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Objective: The purpose of this study was to examine the levels of cerebrospinal fluid (CSF) apolipoprotein E (apoE) species in Alzheimer's disease (AD) patients.

Methods: We analyzed two CSF cohorts of AD and control individuals expressing different APOE genotypes. Moreover, CSF samples from the TgF344-AD rat model were included.

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Article Synopsis
  • Genetic variants in YWHAZ are linked to psychiatric disorders like autism and schizophrenia, impacting neurodevelopment in both humans and mice.
  • In zebrafish, ywhaz is found to be crucial for neuronal development, with its expression changing from widespread in early stages to specific in adult Purkinje cells, which are often impaired in autistic individuals.
  • Research showed that knocking out ywhaz leads to altered brain activity, decreased monoamines, and behavior changes in adult fish, indicating its role in neuronal connectivity and neurotransmission regulation.
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A versatile, functional nanomaterial for the removal of ionic and non-ionic pollutants is presented in this work. For that purpose, the high charge mica Na-4-Mica was exchanged with the cationic surfactant (CHNH(CH)). The intercalation of the tertiary amine in the swellable nano-clay provides the optimal hydrophilic/hydrophobic nature in the bidimensional galleries of the nanomaterial responsible for the dual functionality.

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