Publications by authors named "F Jansen"
Purpose: Limited data exists on the long-term course of fear of cancer recurrence (FCR) in head and neck cancer (HNC) patients. One in five patients was found to experience persistent high FCR in the first months after diagnosis. This study assessed the 3-year trajectories and associated factors of FCR in newly diagnosed HNC patients.
View Article and Find Full Text PDFObjective: Previous retrospective studies have reported vigabatrin-associated brain abnormalities on magnetic resonance imaging (VABAM), although clinical impact is unknown. We evaluated the association between vigabatrin and predefined brain magnetic resonance imaging (MRI) changes in a large homogenous tuberous sclerosis complex (TSC) cohort and assessed to what extent VABAM-related symptoms were reported in TSC infants.
Methods: The Dutch TSC Registry and the EPISTOP cohort provided retrospective and prospective data from 80 TSC patients treated with vigabatrin (VGB) before the age of 2 years and 23 TSC patients without VGB.
Article Synopsis
- Plant communities consist of species with varying functional traits and evolutionary backgrounds, leading to the expectation that functional diversity increases with phylogenetic diversity.* -
- Contrary to this expectation, a study of over 1.7 million vegetation plots showed that functional and phylogenetic diversity are weakly and negatively correlated, suggesting they operate independently.* -
- Phylogenetic diversity is more pronounced in forests and reflects recent climate, while functional diversity is influenced by both past and recent climate, highlighting the need to assess both types of diversity for ecosystem studies and conservation strategies.*
Hypothalamic inflammation often coincides with cancer and cachexia-anorexia. Prior work established the significance of tumor-derived inflammatory factors in triggering hypothalamic inflammation, yet the precise mechanisms remained elusive. Here, we demonstrate that prostaglandin E2 (PGE2), produced in the tumor via cyclooxygenase-2 (COX-2), plays a pivotal role in this context.
View Article and Find Full Text PDFArticle Synopsis
- * A pathogenic variant was found in 31% of the total cases analyzed, with higher rates in specific conditions like focal cortical dysplasia type II (33%) and hemimegalencephaly (62%), particularly involving the mTOR signaling pathway.
- * The identification of germline and somatic variants, especially in focal epilepsy genes, provides insights for future analyses on genetic factors related to surgical outcomes, which could enhance patient counseling and treatment plans.