Publications by authors named "F J de Sauvage"

Confronting escalating challenges in energy security and environmental sustainability has intensified interest in renewable sources for fuels and chemicals. Among the most promising alternatives, sugars derived from biomass are emerging as a cornerstone in advancing an environmentally sustainable economy. Within this framework, the development of sunlight-driven carbohydrate oxidation is of significant interest, as it enables the production of a broad spectrum of high-value, bio-sourced chemicals through eco-friendly processes.

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Oncogenic mutations that drive colorectal cancer can be present in healthy intestines for long periods without overt consequence. Mutation of Adenomatous polyposis coli (Apc), the most common initiating event in conventional adenomas, activates Wnt signalling, hence conferring fitness on mutant intestinal stem cells (ISCs). Apc mutations may occur in ISCs that arose by routine self-renewal or by dedifferentiation of their progeny.

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Article Synopsis
  • The paper discusses the potential of carbon quantum dots (CQDs) as a dual-function tool for both inhibiting collagen fibers and using light to destroy them, which could provide a new treatment for eye floaters.
  • The authors express concern over the safety and efficacy of CQDs in this application, urging further research to fully understand their effects.
  • This study highlights the implications of using nanotechnology in medical treatments, particularly in addressing common visual issues like eye floaters.
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The toxicity of tacrolimus metabolites and their potential pharmacodynamic (PD) interactions with tacrolimus might respectively explain the surprising combination of higher toxicity and lower efficacy of tacrolimus despite normal blood concentrations, described in extensive metabolizers. To evaluate such interactions, we produced tacrolimus metabolites in vitro and characterized them by high resolution mass spectrometry (HRMS, for all) and nuclear magnetic resonance (NMR, for the most abundant, M-I). We quantified tacrolimus metabolites and checked their structure in patient whole blood and peripheral blood mononuclear cells (PBMC).

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