Publications by authors named "F J Van Schooten"
Article Synopsis
- Nucleotide excision repair (NER) is essential for fixing DNA damage from toxins, and a European study aimed to compile data on NER activity.
- The study analyzed NER activity from 738 individuals using blood samples, highlighting that females generally had higher NER activity than males, especially among older women.
- The findings also indicated that having a normal BMI correlated with higher NER activity, while smoking appeared to impact NER differently between sexes; however, the broader implications of varying NER levels for health remain uncertain.
Volatolomics (or volatilomics), the study of volatile organic compounds, has emerged as a significant branch of metabolomics due to its potential for non-invasive diagnostics and disease monitoring. However, the analysis of high-resolution data from mass spectrometry and gas sensor array-based instruments remains challenging. The careful consideration of experimental design, data collection, and processing strategies is essential to enhance the quality of results obtained from subsequent analyses.
View Article and Find Full Text PDFStudy protocol: the 'Endoscope CRC' cohort, a prospective biobank study on the development and evaluation of diagnostic and prognostic biomarker profiles for colorectal cancer and premalignant lesions.
BMJ Open
November 2024
Article Synopsis
- Early detection of colorectal cancer (CRC) can reduce mortality, but existing screening methods like the faecal immunochemical test (FIT) often yield false results, highlighting the need for more accurate tools.
- Research is being conducted on volatile organic compounds (VOCs) found in breath and faeces as potential biomarkers for diagnosing and tracking colorectal neoplasia.
- The study will involve sampling from individuals in the Dutch CRC screening program and utilizes advanced techniques like gas-chromatography-mass spectrometry (GC-MS) along with machine learning for data analysis.
Background: Inhalation is one of the main exposure routes to nanoplastics. Knowledge of the toxicological impact of nanoplastics on the airway- and lung epithelium is limited and almost exclusively based on submerged in vitro models using spherical polystyrene (PS) particles.
Methods: Mono-cultures and advanced (co-)cultures of human bronchial- and alveolar epithelial cells, all air-liquid interface (ALI) cultures, were exposed to nanoplastics and reference nanoparticles.
Mitochondrial abnormalities in lung epithelial cells have been associated with chronic obstructive pulmonary disease (COPD) pathogenesis. Cigarette smoke (CS) can induce alterations in the molecular pathways regulating mitochondrial function in lung epithelial cells. Recently, heated tobacco products (HTPs) have been marketed as harm reduction products compared with regular cigarettes.
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