Publications by authors named "F J Torres-Velez"
Cutaneous myiasis caused by various Calliphoridae dipteran species is prevalent worldwide and is of particular veterinary and public health concern. Recently, in a scientific exploration of the Guinea Worm Eradication Program to Chad, Africa, we observed that dogs with mutilated ears, based on local awareness, were caused by cutaneous myiasis. In this study, we analyzed epidemiological, morphological, and molecular data on cutaneous myiasis in dogs from Chad.
View Article and Find Full Text PDFThis report summarizes the status of the global Dracunculiasis Eradication Program as of the end of 2021. Dracunculiasis (Guinea worm disease) has been eliminated from 17 of 21 countries where it was endemic in 1986, when an estimated 3.5 million cases occurred worldwide.
View Article and Find Full Text PDFInhalation of ricin toxin (RT) elicits profuse inflammation and cell death within the upper and lower airways, ultimately culminating in acute respiratory distress syndrome. We previously reported that the effects of pulmonary RT exposure in mice are nullified by intranasal administration of an mAb mixture consisting of PB10, directed against ricin's enzymatic subunit (RTA), and SylH3, directed against ricin's binding subunit (RTB). We now report that delivery of PB10 and SylH3 as an RT-mAb immune complex (RIC) to mice by the intranasal or i.
View Article and Find Full Text PDFInvestigating Flubendazole as an Anthelmintic Treatment for Guinea Worm (Dracunculus medinensis): Clinical Trials in Laboratory-Reared Ferrets and Domestic Dogs in Chad.
Am J Trop Med Hyg
February 2022
Article Synopsis
- Dracunculus medinensis, known as Guinea worm, is a parasitic infection targeting both humans and domestic dogs, prompting the need for new treatment methods due to rising infections in dogs.
- Two clinical trials tested the effectiveness of flubendazole (FBZ) injections on GW infections: one on ferrets and another on dogs in Chad, revealing different results between the two.
- Ferrets showed promising results with reduced worm viability, while the dog trial did not demonstrate significant effects, indicating that treatment timing and intervals might need to be adjusted for better outcomes in future research.
The progression and systemic pathobiology of in the absence of a microbiota have not been described. Here, we describe the influence of the microbiota during the first 5 days of infection in germ-free or antibiotic-depleted mice. Depletion of the bacterial microbiota in both germ-free and antibiotic-depleted models results in a modest but important increase in the early stages of infection.
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