Comparison of a non-invasive point-of-care measurement of anemia to conventionally used HemoCue devices in Gambella refugee camp, Ethiopia, 2022.

Annual surveys of refugees in Gambella, Ethiopia suggest that anemia is a persistent public health problem among non-pregnant women of reproductive age (NP-WRA, 15-49 years). Measurement of anemia in most refugee camp settings is conducted using an invasive HemoCue 301. We assessed the accuracy and precision of a non-invasive, pulse CO-oximeter in measuring anemia among NP-WRA in four Gambella refugee camps.

Modified latex glove model for simulating a range of supermicrosurgical vessels.

Accessibility of simulated submillimetre vessels for training supermicrosurgeons is limited by cost and access to micro laboratory facilities. Common simulation techniques include in vivo rat mesenteric artery, ex-vivo cryopreserved artery, ex-vivo chicken wing or thigh and synthetic models such as silicone tubing. The lowest cost and most readily accessible of these is the chicken wing model (Hayashi et al.

Assessing serial recall as a measure of artificial grammar learning.

Introduction: Implicit statistical learning is, by definition, learning that occurs without conscious awareness. However, measures that putatively assess implicit statistical learning often require explicit reflection, for example, deciding if a sequence is 'grammatical' or 'ungrammatical'. By contrast, 'processing-based' tasks can measure learning without requiring conscious reflection, by measuring processes that are facilitated by implicit statistical learning.

A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer.

RAS is a common driver of cancer that was considered undruggable for decades. Recent advances have enabled the development of RAS inhibitors, but the efficacy of these inhibitors remains limited by resistance. Here, we developed a pan-RAS inhibitor, ADT-007, that binds nucleotide-free RAS to block GTP activation of effector interactions and MAPK/AKT signaling, resulting in mitotic arrest and apoptosis.

Evolution: Molting regulation by ecdysone is conserved in Tardigrada.

Molting is a key feature of Ecdysozoa, but little is known about the regulation of this process in most ecdysozoans. A new study demonstrates that molting is regulated by the ecdysteroid hormone in the tardigrade Hypsibius exemplaris.