Publications by authors named "F J Sanchez Montero"
The ubiquitin E2 variant domain of TSG101 (TSG101-UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101-UEV/PTAP interactions has emerged as a promising strategy for the development of host-oriented broad-spectrum antivirals with low susceptibility to resistance. TSG101 is a challenging target characterized by an extended and flat binding interface, low affinity for PTAP ligands, and complex binding energetics.
View Article and Find Full Text PDFParasitism involves diverse evolutionary strategies, including adaptations for blood feeding, which provides essential nutrients for growth and reproduction. (Polyopisthocotyla: Microcotylidae), an ectoparasitic flatworm, infects the gills of gilthead seabream (), significantly affecting fish health, welfare and Mediterranean cage farm profitability. Despite its impact, limited information exists on its feeding behaviour.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the diplectanid monogenean, a common gill parasite of the gilthead seabream found in the Mediterranean Sea, aiming to understand its population structure and genetic diversity through molecular analysis.
- Researchers analyzed samples from wild and cage-reared gilthead seabream across fifteen locations in Tunisia, Italy, and Spain, revealing that there is likely just one species of the parasite widespread throughout the region, with evidence of recent population expansion.
- The study shows high haplotype diversity and significant genetic variation among the parasite populations, with notable differences between those in the Adriatic Sea and other areas, suggesting considerable gene flow due to host movement.
Background: Injecting, smoking, and snorting heroin/synthetic opioids is each associated with unique health risks. It is unclear how route of administration (ROA) preferences have shifted during the opioid epidemic.
Methods: Using 2000-2021 admissions data from SAMHSA TEDS-A, we analyzed trends in heroin/synthetic opioid ROA preferences and factors associated with these preferences.
The SARS coronavirus 2 (SARS-CoV-2) epidemic remains globally active. The emergence of new variants of interest and variants of concern (VoCs), which are potentially more vaccine-resistant and less sensitive to existing treatments, is evident due to their high prevalence. The prospective spread of such variants and other coronaviruses with epidemic potential demands preparedness that can be met by developing fast-track workflows to find new candidates that target viral proteins with a clear and phenotype.
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